Our work over the past three years investigating how the OPRM1-A118G single-nucleotide polymorphism (SNP) affects alcohol and opioid reward in a humanized mouse model (h/mOPRM1-A118G) is now in press. In collaboration with Markus Heilig (NIAAA) and Annika Thorsell (University of Linköping), our data on how this SNP affects alcohol-related behaviors in mice appears in Biological Psychiatry; and in collaboration with Markus Heilig and Bryan Roth (UNC), our data on μ-opioid receptor (MOR) reserve differences in 118AA and 118GG mice in Neuropsychopharmacology (see Publications page). Cudos, as always, to Elliott Robinson for bringing this exciting story to fruition. Thanks also to Eyal Vardy and Kate White (alumni of the Roth Lab), Vladimir Chefer (NIDA), and alumni of the Malanga Lab (Jeff DiBerto, Michael Krouse, Eric Fish, and Meng Chen) for what has been a highly successful, multi-investigator team effort!

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